Abstract
This paper highlights the main causes leading the development of insulin resistance (IR), its mechanisms, and the role it plays in living activity. The analysis of the available literature gives reason to believe that the source of IR is the constant requirement for plastic and high-energy compounds to be mobilized from the body's internal reserves. The mechanisms underlying the development IR involve all organ systems that interact between themselves and thereby govern the origin and evolution of insulin resistance via regulation of the energy generation and consumption processes. This concept is in excellent agreement with the laws of thermodynamics. The vital activity is based on the principle of continuous variations of IR. This inference provides a basis for addressing a number of clinical problems.
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