Insulin resistance in non-obese adolescents with family history of type 2 diabetes

Abstract

Objective To investigate the changes of insulin resistance and related risk factors in non-obese adolescents with family history of type 2 diabetes. Methods 80 non-obese adolescents aged 13-15 years with or without family history of diabetes[FH+ group (n = 40) and FH- group (n = 40)] were included in this study. Anthropometric measurements, including height, weight, waist circumference and blood pressure were performed. Blood samples were collected and fasting plasma glucose(FPG), serum lipids, true insulin (TI) and soluble intercellular adhesion molecule-1 (sICAM-1) were assayed. Results FH1 group had performed significantly higher levels of body mass index (BMI), waist circumference, FPG, TI, homeostasis model assessment for insulin resistance (HOMA-IR) and slCAM-1 than FH-group (P<0. 05). HOMA-IR showed positive correlation with BMI (r = 0. 353), waist circumference (r = 0.338), FPG (r = 0. 463), TI (r =0.991) and sICAM-1 (r=0. 161, all P<0.05). In multiple linear regression analysis, waist circumference (β=0.047, P<0.01) and sICAM-1 (β=0. 074, P=0. 014) were significant independent predictors for In (HOMA-IR). Conclusions These results indicate that insulin resistance exists in non-obese adolescents with family history of type 2 diabetes. Visceral fat accumulation and endothelial dysfunction are associated with insulin resistance. Key words: Diabetes mellitus,type 2 ;  Family history;  Insulin resistance ;  Adolescents