Insulin resistance and hyperandrogenism

Abstract

Insulin resistance(IR)is a pathological condition in which the body′s systemic metabolic response to insulin is impaired, including decreased glucose uptake and utilization, suppression of lipolysis and acceleration of production, and disorders in the synthesis of proteins and glycogen.Hyperandrogenism(hyperandrogenemia, HA)refers to a series of clinical manifestations such as hirsutism, acne and masculinity caused by the increase of the androgen level or the activity in the body.IR and HA are the major hallmarks of diseases such as polycystic ovarian syndrome(PCOS)and insulin resistance syndrome.The role of both in the development of the disease has been a topic of debate.Androgen levels and the severity of IR are closely related, but the exact interaction between the two and the causal relationship is not yet fully understood.In recent years, great progress has been made in the research of these problems.This article gives a review of the research progress on the relationship between insulin resistance and hyperandrogenism. Key words: Insulin resistance; Hyperandrogenemia; Insulin; Androgens