Insulin resistance and chronic inflammatory dermatoses

Abstract

Recently, the impact of insulin resistance (IR) on the possibility of increasing the risk of skin diseases has attracted increasing attention of scientists. The causes of comorbid conditions have not been finally clarified. Determining the role of IR in the mechanism of development of dermatoses can affect the diagnosis and effectiveness of treatment. Objective — to analyze literary sources that highlight research on the relationship between IR and some diseases of the skin and its appendages, as well as to find out possible mechanisms of interaction. Materials and methods. The literature search was carried out using key words (IR, psoriasis, acne, adult acne, androgenetic alopecia, pathogenesis), sources from the databases of V.I. Vernadskyi National Library of Ukraine, PubMed, Web of Science and Scopus. Preference was given to sources published in the last 5 years. Results and discussion. The literature review presents a specific and possible relationship between the development of psoriasis, acne vulgaris, acne tarda, androgenetic alopecia and IR based on updated data. IR is considered as a disturbed biological response of the body’s peripheral tissues (muscle, fat, and liver) to the influence of endogenous or exogenous insulin. Analysis of the literature proved that patients with chronic dermatoses have a high risk of developing IR. There are multiple molecular factors responsible for the close association of IR with the metabolic syndrome. Adipokines play a key role in both conditions. Conclusions. IR is an important independent factor in the development of many inflammatory skin diseases, acting both independently and through associated metabolic disorders. It has been established that excess body weight and obesity are significantly associated with IR and the adverse course of dermatoses, so it is advisable for patients to determine HOMA­IR. The severity of chronic inflammatory dermatoses (psoriasis, adult acne, and AGA) is considered an independent predictor of IR.