Abstract
sBackground and objectiveThe study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA)Subjects and methodsWe recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I (with BMI catch-up) and II (without BMI catch-up) respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height. Their serum fasting insulin, fasting glucose, insulin-like growth factor-1, adiponectin, IGFBP-1, triglyceride concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) were evaluated.Results(1) The HOMA-IR values in SGA-I with catch-up growth group were significantly higher than those in SGA-II with catch-up growth, SGA-I without catch-up growth and AGA children respectively. (2) The serum adiponectin levels of individuals in the SGA-I without catch-up growth and SGA-II with catch-up growth groups were significantly lower than those from the SGA-II without catch-up growth group. There was no difference in triglyceride or IGFBP-1 levels among the groups. (3) The degree of HOMA-IR was positively correlated with age, current BMI and △height SDS in SGA children.ConclusionThe development of insulin resistance and lower levels of adiponectin were closely correlated with higher BMI and the postnatal height catch-up growth in SGA children.
Highlights
Epidemiological studies have suggested that children born small for gestational age (SGA) are at higher risk for developing metabolic syndromes in adulthood, including insulin resistance, type 2 diabetes, and cardiovascular diseases [1,2,3]
Subjects and methods: We recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I and II respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height
The development of insulin resistance and lower levels of adiponectin were closely correlated with higher body mass index (BMI) and the postnatal height catch-up growth in SGA children
Summary
Epidemiological studies have suggested that children born small for gestational age (SGA) are at higher risk for developing metabolic syndromes in adulthood, including insulin resistance, type 2 diabetes, and cardiovascular diseases [1,2,3]. Previous studies have shown that children born SGA with catch-up growth exhibit fat accumulation, abnormal development of adipose tissue and adipocyte function caused by adverse intrauterine growth, which contributes to the development of insulin resistance [4,5,6,7]. The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA)
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