Abstract
This chapter touches on selected aspects of the regulation of glycogen synthase by insulin in rat heart and liver. An update on this area would seem timely due to reports during the past 10 years of reproducible insulin effects on glycogen synthase in perfused rat hearts and isolated rat liver preparations. While considerable work has been carried out in rat heart and liver preparations in vitro,the mechanistic knowledge of glycogen synthase regulation remains far behind that reported for rabbit skeletal muscle. The purpose of this chapter is to attempt to summarize recent knowledge related to the insulin regulation of rat heart and liver glycogen synthase and to present recent data pertinent to insulin action from our laboratory.
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