Abstract
The peptide hormone, insulin-like growth factor I (IGF-I) is a growth factor which has been shown in elevated concentrations in the serum and vitreous of diabetic patients with proliferative diabetic retinopathy. Studies with an animal model of IGF-I induced proliferative retinopathy2 showed demyelination in the optic nerves and along the medullary rays of rabbit eyes which received intravitreal injections of IGF-I, basic fibroblast growth factor (bFGF), or a combination of the two growth factors. Biochemical studies have demonstrated a role for oxidative injury in complications of diabetes including lipid peroxidation and demyelination in peripheral neuropathy. The cerium NADH-oxidase technique has been used to demonstrate free radical derived oxidant production in several pathological conditions including demyelination in experimental allergic encephalomyelitis (EAE). We investigated the role of free radical derived oxidants in growth factor-induced demyelination.Pigmented rabbits were injected intravitreally with 500 μg of IGF-I or bFGF and sacrificed at 4, 8,12 and 18 days.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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