Abstract
Objective: Insulin-like growth factor-1 (IGF-1) plays a role in survival, growth, proliferation and differentiation of various cell types. In atherosclerosis, IGF-1 has been shown to stimulate vascular smooth muscle cell (SMC) proliferation, migration and extracellular matrix (ECM) synthesis contributing to maintenance of plaque stability. Consequently, a reduction of IGF-1 in atherosclerotic plaques has been suggested to increase SMC apoptosis and reduce ECM synthesis leading to weakening of the plaque. Not much is known about the effects of endogenous and exogenous IGF-1 in human aortic valve (hAV) tissue that suffers from calcification and tissue mineralization leading to Aortic Valve Stenosis (AVS). The objective of the present study is therefore to investigate potential function of IGF-1 in this disease model.
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