Insulin-Like Growth Factor-1 in Acute Ischemic Stroke

Hala Shaheen,Sayed Sobhy,Manal Niazi,Sherine El Mously,Mohammed Gomaa

doi:10.1186/s41983-018-0042-y

Abstract

BackgroundCerebrovascular ischemic stroke is highly prevalent in the general population and is considered one of the frequent causes of mortality and disability. Insulin-like growth factor-1 (IGF-1) is recognized as an important neuro-protective factor against cerebral vascular ischemic insult.Aim of the workTo study the relationship between serum IGF-1 levels and acute ischemic stroke (AIS) in the Egyptian population.Patients and methodsTwo hundred patients with AIS (within the first 24 h) were subjected to full neurological examination, assessment of stroke severity using National Institute of Health Stroke Scale (NIHSS) and measurement of serum IGF-1 levels. The control group included 100 subjects matched for age, gender, and conventional vascular risk factors.ResultsSerum IGF-1 levels were significantly reduced in cases of first AIS compared to control group. A reduced serum IGF-1 level was an independent risk factor for ischemic stroke with cut off value less than 148.3 ng/ml associated with increased AIS risk.ConclusionLower IGF-1 levels are significantly related to risk of ischemic stroke occurrence, independent from other conventional risk factors in the Egyptian population.

Highlights

Cerebrovascular stroke is one of the most frequent causes of death and disability worldwide; it has significant clinical and socioeconomic impact [1].The expanding use of biomarkers in the field of stroke has made a substantial impact in our understanding of the pathophysiology of stroke and the treatment approach [2].Insulin-like growth factor-1 (IGF-1) is a single-chain polypeptide hormone composed of 70 amino acids; it shares homology with proinsulin
A reduced serum IGF-1 level was an independent risk factor for ischemic stroke with cut off value less than 148.3 ng/ml associated with increased acute ischemic stroke (AIS) risk
Our study revealed that serum IGF-1 levels were significantly reduced in cases of first AIS compared to controls

Summary

Introduction

Cerebrovascular stroke is one of the most frequent causes of death and disability worldwide; it has significant clinical and socioeconomic impact [1]. Insulin-like growth factor-1 (IGF-1) is a single-chain polypeptide hormone composed of 70 amino acids; it shares homology with proinsulin. It is produced mainly by the liver in response to the endocrine growth hormone (GH) stimulus, but it is secreted by multiple tissues for autocrine / paracrine purposes [3]. Cerebrovascular ischemic stroke is highly prevalent in the general population and is considered one of the frequent causes of mortality and disability. Insulin-like growth factor-1 (IGF-1) is recognized as an important neuro-protective factor against cerebral vascular ischemic insult

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Results

Discussion

Conclusion