Abstract
Benzoic acid precipitate of human urine was studied for its ability to augment production of CO 2 from glucose in adipose tissue. Recovery of this urinary insulin-like activity (UILA) was most efficient after removal of inhibitory activity by dialysis at pH 4 and assay in bicarbonate buffer using epididymal fat pads of fed rats. Partial inhibition of UILA was effected by guinea pig antiinsulin serum. Significant levels of activity were found in urine of obese persons and a further increase of this was noted during starvation. Excretion levels in nonobese controls were significantly lower than those from obese subjects and showed no rise on starvation. The behavior of the UILA most closely resembles that of the plasma albumin fraction described by Alp and Recant.
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