Abstract
Fetal insulin is considered to be an intrauterine growth promoting hormone. Intrauterine growth retardation has been one of the major problems of newborn of drug addicted mothers. Umbilical cord venous blood was collected from full term small for gestational age babies (SGA) born to drug addicted mothers (DA). Controls (C) include normal full term appropriate for gestational age (AGA) and small for gestational age babies of non-drug addicted mothers. Gestational age was assessed by DUBOWITZ and lens examination in all the newborns. The results are as follows: There is significant decrease in insulin leves in SGA newborns as compared to AGA group. The insulin levels of AGA-DA group are significantly lower than AGA-C but significantly higher than SGA-C or SGA-DA. Insulin levels in SGA-DA were significantly lower than in SGA-C. These results suggest that intrauterine growth retardation of newborns of drug addicted mothers is a process mediated by insulin. Further studies are needed.
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