Abstract
In the present experiment, hypoglycaemia was induced by injecting Insulin, in primigravida Charles Foster (CF strain) female rats during early pregnancy and teratogenic effects were studied in new born.On the 9th day of gestation, 20 I.U. of Insulin was injected intra peritoneally in the rats of study group (Average wt =200 gm). At the same time normal saline was injected in the pregnant rats of control group. Fetuses were collected on 20th day of gestation by laparotomy, and were examined by naked eye. Fetal mortality (7%) was observed in treated rats while itwas nil in control group. 48% newborn treated rats showed gross congenital malformations. There was significant growth retardation, cataract, exophthalmos, limb anomalies and haemorrhages over head region in treated fetuses.The present study revealed that the maternal hypoglycaemia even for a brief period, during early pregnancy, induces teratogenic effects ranging fetal mortality to gross malformations. Its implications in the human being.must be seriously taken in to account.
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