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Abstract
The liver plasma membrane preparation devised by Neville (Biochim. Biophys. Acta, 154 , 540 (1968) contains insulin-degrading activity. Examination by chromatography on Sephadex G-75 of the products formed from 125I-insulin upon incubation with plasma membrane showed the same products (A chain and B chain rich-A chain aggregate) as previously found with purified GSH-insulin transhydrogenase (GIT). In Ouchterlony double-diffusion experiments with antibody to purified rat liver GIT, plasma membrane gave a single precipitation band of identity with purified rat liver GIT. Thus, the insulin-degrading activity present in the plasma membrane preparation is indeed GIT.
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