Abstract
Insulin is degraded by rat liver in a sequential manner: first, a splitting of insulin at the disulfide bonds by glutathione-insulin transhydrogenase and second, proteolysis of resultant A and B polypeptide chains to small molecular weight components. In the present studies, we have shown that insulin is degraded sequentially by kidney, heart and skeletal muscle of rat. These findings suggest that this mechanism of insulin degradation is probably a widespread general mechanism; the possibility that this mechanism plays an important role in the disposal and the action of insulin is discussed.
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