Abstract
Microvascular endothelial cells were isolated from rabbit cardiac tissue, and cultivated by standard tissue culture techniques. The conversion of [U-14C]glucose to CO2 and lipids was significantly enhanced by insulin treatment. Insulin stimulated uptake of 2-[3H]deoxyglucose and enhanced the transport of 3-O[3H]methyl-D-glucose. Specific binding of [125I]insulin to RCME cells, displaceable by cold insulin, was also observed. These data demonstrate that insulin is capable of regulating metabolic activities in coronary microvascular endothelium.
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