Abstract
Insulin autoimmune syndrome (IAS),which shows severe spontaneous hypoglycemia without a history of exogenous insulin administration,is contributed by both genetic factors and environmental factors.Most patients carry the gene DRB1 * 0406,and often accompany with other immune disorders,such as Graves' disease.IAS is characterized by high total serum insulin,high C-peptide levels,and a high titer of in-sulin auto-antibodies (IAA).Moreover,administration of methimazole is considered to be an incentive for it.Besides,IAS is self-limiting,and when stop using the triggered drugs,it can be eased by a low carbonhydrate,high protein,and high fiber diet.A small dose of glueocorticoid can also be applyed when necessary. Key words: Insulin autoimmune syndrome ; Hypoglycemia ; Insulin autoantibody ;
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