Abstract
Background and Significance: Previous studies have demonstrated increased levels of maternal serum androgens in pregnancies affected by gestational diabetes (GDM). The mechanism behind this is unclear, but may be similar to that which is seen in polycystic ovarian syndrome (PCOS), where hyperinsulinemia causes hyperandrogenemia. Another possible mechanism could involve human chorionic gonadotropin (hCG) cross-reacting with ovarian luteinizing hormone receptor. Finally, obesity, which is commonly associated with GDM, may play a significant role in androgen production.
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