Abstract
The influence of the structure and physico-chemical properties of chitosan/casein multilayer films on their potential use for drug delivery systems was investigated. The multilayer films were prepared using layer-by-layer self-assembly, whereby chitosan and casein were deposited onto poly(lactic acid) substrates pretreated with either a positive or a negative corona. The corona discharge system consisted of a corona electrode, a grounded plate and a grid. The deposition was studied by ATR FT-IR, AFM, and surface energy measurements. ATR FT-IR spectra proved the formation of polyelectrolyte chitosan — casein complexes. The increasing content of chitosan and casein with increasing number of bilayers was further confirmed by XPS analysis. The surface topography was examined by AFM and the average roughness was evaluated. A comparative analysis of the experimental results was performed and the most appropriate substrate corona treatment for the irreversible binding of the chitosan/casein polyelectrolytes was determined.
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