Abstract
Reduced insula volume is consistently observed in psychotic disorders. High-risk individuals who later transition to psychosis also exhibit smaller insula, suggesting a developmental origin. The insula is a complex structure comprised of agranular, dysgranular, and granular areas which differ in their cytoarchitecture and are implicated in distinct functions; however differential alterations in these areas are rarely investigated. In particular, the agranular and dysgranular insula are critical for higher-order cognition, which is often a pre-morbid marker of psychosis risk.
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