Abstract
AbstractBackgroundEstimates suggest that between 30% and 40% of all AD cases are attributable to potentially modifiable risk factors such as hypertension, midlife obesity, diabetes mellitus, depression, social isolation, physical inactivity, smoking, low level of education, and hearing loss (Barnes and Yaffe 2011; Livingston et al. 2020; Luck and Riedel‐Heller 2016). In addition, other risk factors for AD such as stress and sleep disturbances have been identified in recent years (Escher et al. 2019; Sindi et al. 2018). The Individual risk profiling for Alzheimer's disease and dementia prevention (INSPIRATION) study aims to explore the frequency and distribution of risk factors for AD in the participants of an Alzheimer Prevention Registry in order to establish individualized risk profiles and aid the development of personalized prevention programs.MethodCross‐sectional assessment of healthy study participants aged 50 or older recruited through a local volunteer Alzheimer Prevention Registry is performed to determine the prevalence of key risk factors. This protocol includes established questionnaires and medical examination. Data is collected on demographics, medical history, family history, physical activity, diet, BMI, waist circumference, hearing loss, smoking and drinking habits, presence of depression, anxiety, stress, resilience, and loneliness. In addition, we perform neuropsychological testing and blood sampling for ApoE determination and AD‐biomarker testing. The aim is to enroll 200 individuals.ResultPreliminary results in 32 participants indicate that the three most frequent risk factors were non‐adherence to recommended diets (i.e. Mediterranean diet) in 84.4% of the subjects, obesity in 68.8% with a mean BMI of 27.6 kg/m2 (22.3‐41.6kg/m2, min./max.), and sleep problems in 50% of the subjects. The full set of assessed risk factor will be presentedConclusionThe INSPIRATION study aims to understand the prevalence of modifiable AD risk factors, in order develop a tool box of interventions for personalized strategies to prevent AD in a population, which is particularly interesting in dementia prevention.
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