Abstract
To better understand the mechanism of intracellular Ca 2+ mobilization, mouse oocytes were micro-injected with ‘caged’-inositol-1,4,5 trisphosphate (caged-InsP 3) together with the Ca 2+ indicator Fluo-3 ??? and monitor Ca 2+ redistribution. Photo-released InsP 3 olicits [Ca 2+], changes exhibiting several kinetics phases and threshold ??? oscillations were induced after a single InsP 3 pulse. Autoregenerative Ca 2+ transients could also be induced by injections of Ca 2+ itself, demonstrating unequivocally the presence of a Ca 2+-induced Ca 2+-release mechanism in these cells.
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