Abstract
BackgroundThe health benefits of dietary fibre (DF) intake on non-alcoholic fatty liver disease (NAFLD) are controversial. Thus, this large cross-sectional study aimed to determine the associations between DF intake and the prevalence of newly-diagnosed NAFLD in a large general population.MethodsA total of 23,529 participants were enrolled in the analyses. Newly-diagnosed NAFLD was diagnosed according to liver ultrasonography and history of alcohol intake. DF intake was assessed using a validated self-administered food frequency questionnaire. Logistic regression analysis was applied to estimate the associations between DF intake and NAFLD.ResultsIn total, 18.81% (n = 4426) of the participants were newly diagnosed with NAFLD. Compared with the participants in the lowest quartile of DF intake, the ORs (95% CI) for the participants in the highest quartile were 0.81 (0.67, 0.97), 0.78 (0.62, 0.99), and 0.85 (0.62, 1.17) for all participants, men, and women, respectively. Compared with the participants in the lowest quartile of insoluble DF intake, the ORs (95% CI) for the participants in the highest quartile were 0.70 (0.58, 0.85), 0.60 (0.47, 0.76), and 0.95 (0.68, 1.32) in all participants, men, and women, respectively. No association was observed between soluble DF intake and NAFLD. DF from whole grain, soy foods, vegetables, and nuts but not fruits were negatively associated with NAFLD.ConclusionsA higher intake of insoluble DF is associated with lower prevalence of newly-diagnosed NAFLD in men. Moreover, intake DF from whole grain, soy foods, vegetables, and nuts, but not fruits have favorable effect on the prevalence of newly diagnosed NAFLD. Further cohort studies and randomized controlled trials are needed to validate this finding.
Highlights
Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with obesity, insulin resistance, type 2 diabetes mellitus, hypertension, hyperlipidaemia, and metabolic syndrome [1]
Participant characteristics Among the 23,529 participants who were eligible for the final analyses, 4426 (18.81%) had newly-diagnosed non-alcoholic fatty liver disease (NAFLD)
dietary fibre (DF) from vegetables (Q4 VS Q1: Odds ratio (OR), 0.73; 95% confidence interval (CI), 0.57–0.94) and nuts (Q4 VS Q1: OR, 0.75; 95% CI, 0.60–0.94) intake were negatively associated with the prevalence of newly diagnosed NAFLD after multivariable adjustments
Summary
Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with obesity, insulin resistance, type 2 diabetes mellitus, hypertension, hyperlipidaemia, and metabolic syndrome [1]. Urbanisation of many Asian countries in the past 2 decades has led to the prevalence of sedentary lifestyles and overnutrition, setting the stage for the epidemic of obesity and NAFLD [2]. Considering the disease burden and high prevalence of NAFLD, it is important to identify modifiable risk factors and develop preventive strategies. The health benefits of dietary fibre (DF) intake on non-alcoholic fatty liver disease (NAFLD) are controversial. This large cross-sectional study aimed to determine the associations between DF intake and the prevalence of newly-diagnosed NAFLD in a large general population
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