Insilico Studies on Antimicrobial Peptides (AMPs) from Earthworm

Abstract

The immune system of earthworm is very robust despite being in a primitive invertebrate organism. The immune system confers protection against pollutants and pathogens (Ghosh in Environ Sci Pollut Res 25:6196, 2018) and the cells and molecules in the earthworm coelomic fluid are reported (Bilej et al. In: Madame Curie bioscience database [Internet]. Landes Bioscience, Austin, TX, 2000–2013) to play antibacterial, antitumoral and anti trypanosomal role and contain immune molecule including coelom cytolytic factor (CCF), lyesenin and antimicrobial peptides (AMPs). Due to their diverse and advanced roles, they find importance for study both from the point of view of basic sciences and applied biological sciences. Although the immune molecules are reported from different species of earthworm, the physiochemical proteins of AMPs are yet to be studied. Therefore, we performed an insilico study of the different AMPs reported from different species of earthworm from the NCBI. We report for the first time, diversity amongst the AMPs of different species of earthworms, despite functional similarities.