In-Silico Studies of Alzheimer’s Disease Affected Brain Using a Novel Terahertz Thermography Technique

Abstract

Alzheimer's disease (AD) is a dynamic disorder that causes brain cells to become extremely thin or weak and dies. Alzheimer's disease is the most widely recognized reason for dementia, a persistent decrease in thinking, behavioural and social aptitudes that disturbs an individual's capacity to work autonomously. This paper for the first time reports a new scheme of diagnosis of AD by studying the corresponding Terahertz (THz) thermographs. A solid-state source of THz radiation (IMPATT oscillator), capable of working at room temperature, is proposed in this paper and the THz non-linear characteristic of the device and system are studied through an in-house developed quantum modified classical drift diffusion simulator. A COMSOL-based THz-thermograph model is further developed and a comparative analysis of normal brain tissues and AD affected brain tissues thermographs are reported. To the best of authors’ knowledge, this is the first report on studying of the prospects of an exotic type non-invasive Terahertz ⟨ p+−n−n+⟩ radiation source for use in T-Ray thermography studies of AD detection with Terahertz radiation exposure.KeywordsAvalanche transit time deviceAlzheimer’s diseaseLarge-signal impedance and admittance studyNoise-studyNon-linear quantum drift diffusion simulatorRoom temperature characteristicsTerahertz source and radiation systemT-Ray thermograph study