Insilco Design and Potential Cytotoxic agents EGFR Inhibitors of 4(3H) Quinazolinone Derivatives

Abstract

Epidermal growth factor receptor (EGFR) acting very important part in cell growth regulation, one of the most significant consideration studied targets of tyrosine kinases (TK) inhibitors. A number of TKs take component in the role cell proliferation, differentiation and metastasis, survival and tolerant activation by mechanisms for instance point mutation might show the way to huge proportion of clinical cancers. EGFR is in excess articulated within many tumors, as well as ovarian, breast and bladder, head, brain, prostate, lung tumors. based in the field of literature study found that the invention of quinazolin 4(3H) one derivatives of structural modifications which produce their potential of cytotoxic properties. By inhibit the EGFR-TKs enzyme. In this, we introduced newly synthesized quinazolinones compounds to systematically investigate binding affinity and drug likeliness property against EGFR-TKs. the interaction of newly synthesized molecules QOC1-QOC6 against 1M17 Protein five derivatives of quinazolinone an induced fit docking analysis indicated are involved in binding affinity. The present study aimed at studies showed with the systematic analysis, the newly synthesized potential quinazolinone are recommended so as to these molecules would provide the same as enhanced show the way lead moiety for cytotoxic activity.