Abstract
Despite the exciting breakthroughs in medical technology, cancer still accounts for one of the principle triggers of death and conventional therapeutic modalities often fail to attain an effective cure. Recently, nanobiotechnology has made huge advancement in cancer therapy with gigantic application potential because of their ability in achieving precise and controlled drug release, elevating drug solubility and reducing adverse effects. Carbon nanotubes (CNTs), one of the most promising carbon-related nanomaterials, have already achieved much success in biomedical field. Due to their excellent optical property, thermal and electronic conductivity, easy functionalization ability and high drug loading capacity, CNTs can be applied in a multifunctional way for cancer treatment and diagnosis. In this review, we will give an overview of the recent progress of CNT-based drug delivery systems in cancer theranostics, which emphasizes their targetability to intracellular components of tumor cells and extracellular elements in tumor microenvironment. Moreover, a detailed introduction on how CNTs penetrate inside the tumor cells to reach their sites of action and achieve the therapeutic effects, as well as their diagnostic applications will be highlighted.Graphic
Highlights
Cancer is one of the deadest diseases that causes an increasing mortality rates over the past decades [1]
Luo et al designed a nanosystem composed of multiwall carbon nanotubes (MWNTs)-loaded ginsenoside Rg3 (Rg3-Carbon nanotubes (CNTs)) for triplenegative breast cancer (TNBC) treatment, which firstly demonstrated the new function of Rg3-CNT in elevating the therapeutic efficacy of Rg3 against TNBC through the inhibition of Programmed cell death protein 1 (PD-1)/Programmed cell death ligand 1 (PD-L1) axis, providing a potential strategy for TNBC treatment through immunotherapy [78]
Conclusion and future prospect This review gives a summary of the update advances of CNTs in cancer theranostics
Summary
Cancer is one of the deadest diseases that causes an increasing mortality rates over the past decades [1]. Achieve active targeting ability Head and neck squa- Show negligible toxicity and enhance the uptake of mous carcinoma in vitro and in vivo drugs surface, successfully delivering siRNAs into cells and resulting in higher transfection and gene silence efficiency.
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