Abstract
Breast cancer is the most common cancer across the globe occurring commonly in women population, and it is one of the main causes of mortality in women. In 2018, 1,62,468 new cases and 87,090 death cases of breast cancer were registered in India. In these recent years, lots of studies were conducted in breast cancer related to treatment and management, but in spite of getting so much advancement in the treatment of breast cancer still, the mortality rate of women is increasing day by day. Numerous factors are acting as barriers or challenges in breast cancer preventive therapy. It includes lack of knowledge regarding the treatment of cancer and patient getting insecure about treatment, fear of having side effects, cost of treatment and the efficacy of the drugs being prescribed. The study intended to determine the perceived insights and barriers to treatment of breast cancer.
Highlights
Cancer is a group of diseases identified by unmanageable growth and expansion of abnormal cells that cause life risk leading to death if not managed
This study reveals about the new advancements made in neoadjuvant therapy where Two groups are mainly concentrated for neoadjuvant therapy, which includes, Human Epidermal Growth Factor Receptor 2 (HER2) and triple negative breast cancer
The combination of pertuzumab with trastuzumab and docetaxel was approved by the FDA as first-line treatment for HER2-positive metastatic breast cancer, and it is the first drug to be used in the neoadjuvant therapy by using a full pathological response as an endpoint in the Cleopatra trial
Summary
Cancer is a group of diseases identified by unmanageable growth and expansion of abnormal cells that cause life risk leading to death if not managed. Fear of having side effects, high treatment cost, beliefs/concerns about the medications, confusion between chemotherapy and chemoprevention, having little or no knowledge about the disease are some barriers at the patient side. These factors lead to a higher mortality rate in patients with breast cancer (Park, 2015; Feuer et al, 1993). Obese women after menopause can have a high risk of getting breast cancer as the fatty tissues increases producing a hormone (oestrogen/progesterone). Among the joint investigation of 22 researchers, 11 accepted that at 70 yrs. of age carrying BRCA1 gene, the chance of getting breast cancer is 65% and those carry BRCA2 gene have 45% possibility of getting breast cancer (Nkondjock & Ghadirian, 2004). 5-10% causing breast cancer can transfer from father or mother to the generation in the family
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