Abstract
Although hereditary breast cancers associated with BRCA1 mutations are rare, they are frequently (80%) basal-like as defined by gene array signatures and resemble sporadically occurring basal-like tumors (which usually are triple-negative for estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 [HER2]). Successful treatment approaches to BRCA1 -associated breast cancers, therefore, might also be effective in sporadic basal-subtype breast cancers. BRCA1 plays an important role in DNA interstrand cross-link repair; thus, recent evidence that suggests BRCA1 -associated tumors might be …
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