Abstract
Dengue virus is the most prevalent arthropod-borne virus. It is a part of the flavivirus family and infections with dengue virus can lead to severe dengue disease. There are no clinically approved antiviral drugs for the treatment of dengue infection to date, and vaccines available are limited to seropositive individuals. The non-structural 5 (NS5) protein is the largest protein encoded by flaviviruses and is responsible for the replication of the viral RNA genome. NS5 has an N-terminal methyltransferase (MTase) domain responsible for 5’ RNA capping, and a C-terminal RNA-dependent-RNA-polymerase (RdRp) domain responsible for de novo RNA synthesis.
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