Abstract
COVID-19, the infectious pandemic disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This deadly disease was unknown before its catastrophic outbreak of the infection in Wuhan city of China, in December 2019. The pandemic situation has increased the demand of rapid enhancement of the in-vitro diagnostic assays which would enable the mass screening and testing. Several molecular and serological diagnostics assays such as direct viral antigen tests, nucleic acid amplification tests and serological tests were developed. Nucleic acid tests such as RT-PCR. TrueNAT, Feluda Test, loop-mediated isothermal amplification (LAMP) etc. detect the presence of RNA virus in the nasal or throat swab or from saliva. Antigen tests detect the presence of a virus as the antigen, which is a surface protein. Antibody tests such as enzyme-linked immunosorbent assays (ELISA), lateral flow assays (LFA), chemiluminescence assays (CLIA) etc. detect the presence of antibodies generated against SARS-CoV-2 in the blood samples.
Highlights
Corona, the most infectious pandemic of the decade, is still breaking records each day
The present study focused on the different testing assay developed so far to detect the COVID-19 virus effectively and the mechanism of its action
The test kits like Cobas SARS COV 2 from Roche and Taqpath covid19 combo kit from Thermos fisher are get validated by Indian Council of Medical Research (ICMR).ICMR is functions along with four central depots and sixteen regional depots (Fig. 9) with laboratories for distribution, coordination and validation of COVID-19 testing kits and COVID-19 vaccine development
Summary
FDA – Food and drug Administration 11. NAAT - Nucleic acid amplification test 19. PHEIC - Public Health Emergency of International Concern (PHEIC) 22. QPCR - Quantitative polymerase chain reaction 23.
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