Abstract
The human microbiome represents the entire genome assembly of microorganisms colonizing the human body and comprises more than three million genes that encode thousands of metabolites, which cover several functions essential for the host health condition. Anatomical sites colonized by microorganisms include the skin, gastrointestinal, respiratory, urogenital, and reproductive tract, establishing commensal, mutual, or pathogenic relationships with the organism. The human microbiota is considered a dense ‘organ’ with multiple roles in nutrition, gastrointestinal tract development, and innate immunity training. Depending on the genetic predisposition, type of diet, health status, and lifestyle, this ‘organ’ seems to have a specific unique signature, maintained quasi-stable, establishing symbiotic relationships with the host organism. The disruption of the dynamic balance is established between the human body and its microbiota leads to dysbiosis, which in its turn, could be the origin of a comprehensive spectrum of diseases, ranging from inflammatory, infectious, and cardiovascular diseases to cancer. In this review, we will present several types of malignancies (e.g., head and neck cancers, esophageal, colorectal, cervical, lung, bladder, and skin cancers) and the appearance of the resistance to antitumor therapies. In this minireview we present some insights regarding the implication of human microbiota in non-sterile cavities cancers.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.