Insights into the Roles of Cyclophilin A During Influenza Virus Infection

Xiaoling Liu,Wenjun Liu,Zhendong Zhao

doi:10.3390/v5010182

Xiaoling Liu, Wenjun Liu + Show 1 more

Open Access

https://doi.org/10.3390/v5010182

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Journal: Viruses	Publication Date: Jan 15, 2013
Citations: 84	License type: CC BY 4.0

Affiliation: Wuhan Institute of Virology, Chinese Academy of Sciences

Abstract

Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.

Highlights

Influenza virus is an enveloped negative-sense RNA virus that causes major public health problems worldwide
M1 is a multifunctional protein in the influenza virus lifecycle that is involved in uncoating, transcription, the nuclear export of viral ribonucleoprotein complexes, assembly and budding
Several host cell factors are putatively required for regulation of influenza virus replication via interaction with M1 at different stages of infection [5,6,7,8]

Summary

Introduction

Influenza virus is an enveloped negative-sense RNA virus that causes major public health problems worldwide. Several host cell factors are putatively required for regulation of influenza virus replication via interaction with M1 at different stages of infection [5,6,7,8]. The peptidyl-prolyl cis-trans isomerase Cyclophilin A (CypA) participates in influenza virus infection at several steps [9,10,11,12]. As a ubiquitously expressed host factor, CypA plays important roles in several viral infections [9,11,13,14,15,16,17,18,19]. The aim of this review is to promote our understanding of the effects of CypA during influenza virus infection

The Localization and Function of CypA

CypA as an Important Host Factor in Viral Infections

CypA and Influenza Virus Infection

Conclusion and Future Directions