Insights into the reinforcement role of peritubular dentine subjected to acid dissolution

Abstract

Human dentine is a mineralised dental tissue that consists of dentinal tubules surrounded by two distinct dentinal phases: peritubular dentine (PTD) and intertubular dentine (ITD). Dental caries, which manifests itself as a consequence of demineralisation, is one of the most common chronic diseases that affect the function of human teeth. Due to the difference in the packing density of crystallites, PTD and ITD exhibit different reaction rates to acid dissolution. The present study evaluates how the effective Young's modulus degrades and how the effective stress redistributes in demineralised human dentine as a result of incremental acid dissolution process. An analytical two-layer composite model is proposed and used for the effective Young's modulus calculation. 3D numerical representative volume elements (RVEs) with different variations in PTD fraction and dentinal tubule density are established to evaluate effective stress redistribution and examine the critical factors that can affect the mechanical performance. The models are then applied on an actual dentine bulk sample. The results reveal how PTD serves as a protection to ITD thus highlight the important role that PTD plays for the structural integrity of dentine. The obtained insights are crucial for advancing the understanding of a variety of natural and therapeutic effects from the mechanical perspective, e.g. the mechanical performance assessment of human dentine subject to complex dynamic processes of de- and re-mineralisation that can occur in human dental caries and dental treatments. It will ultimately inspire the biomimetic design towards strengthening the dentine and dentine-like materials.