Abstract
Insights into the invasion biology of Plasmodium vivax
Highlights
Erythrocyte invasion by malaria parasites is a complex and multi-step process involving interaction between parasite ligands and host cell receptors
Erythrocyte invasion by P. vivax is mediated by a single receptor expressed on the surface of erythrocytes and reticulocytes called Duffy receptor, or Duffy antigen receptor for chemokines (DARC) (Horuk et al, 1993)
Duffy binding protein (DBP) is a 140 kD protein located within micronemes of merozoites (Fang et al, 1991; Adams et al, 1992) and it belongs to the family of Duffy binding like erythrocyte binding proteins (DBL-EBP)
Summary
Erythrocyte invasion by malaria parasites is a complex and multi-step process involving interaction between parasite ligands and host cell receptors. Duffy receptor is recognized and bound by Duffy binding protein (DBP) of P. vivax. The absence of Duffy receptor (Duffy negative trait) confers resistance to P. vivax infection (Miller et al, 1976).
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