Insights into the complexation of glucose-6-phosphate (G6P) with V(III), Ru(III), Au(III), and Se(IV) ions in binary solvent system

Abstract

Glucose-6-phosphate (G6P) as a ligand (formulated as LH−) was reacted with V(III), Ru(III), Au(III), and Se(IV) ions. The structures of the obtained complexes were characterized by IR, 1H and 13C NMR, UV–Vis., molar conductance, elemental, and thermal techniques. The antibacterial activity of the complexes towards two Gram-positive and two Gram-negative bacteria were screened in vitro. Furthermore, the cytotoxicity of the Au(III) complex against two different human cancer cell lines was assessed in vitro by the MTT-based cell technique. The spectral, and analytical data suggests that G6P acts as a bidentate ligand coordinating by both oxygen atoms of the phosphate group. This forms a square planar geometry with Au(III) and Se(IV) ions and a octahedral geometry with V(III) and Ru(III) ions. Interestingly, the cytotoxic effect of Au(III) complex towards HepG2 and MCF-7 cell lines was greater than that of the free ligand by approximately 80- and 45-fold, respectively.