Insights into the antibacterial mechanism of MoS2/CoS2 heterostructure nanozymes with double enzyme-like activities for MRSA-infected wound therapy

Abstract

Wounds infected by drug-resistant bacteria have become a worldwide health problem, and conventional antibiotics are no longer effective. On this basis, MoS2/CoS2 heterostructure nanozymes was designed by simple molten salt method. Transmission Electron Microscopy confirmed that the clear interface of MoS2/CoS2 was established creatively, which greatly promoted more distorted lattice generation. Benefited from the heterogeneous interfaces of MoS2/CoS2, the transfer of electrons was accelerated and double enzyme-like activities were improved greatly, which had been confirmed by the experimental characterizations and theoretical calculation. Moreover, the mechanism was investigated in depth based on the electronic state change of MoS2/CoS2 during the peroxidase reaction. Based on the peroxidase avtivity, MoS2/CoS2 could effectively kill drug-resistant bacteria as high as 99%, including Gram-positive and Gram-negative bacteria, it proved the broad-spectrum antibacterial effect of MoS2/CoS2. The results showed the superiority of the synergistic effect of the material and low concentration of H2O2. In addition, MoS2/CoS2 NFs greatly promoted the rapid healing of wounds in vivo and had good biocompatibility. This study provides a simple strategy to engineer nanozymes with enhanced catalytic activity and furnished a potential ideas in the treatment of bacterial infections and wound healing.