Insights into switchable thermoresponsive copolymer layers by atmospheric pressure plasma‐initiated chemical vapour deposition

Abstract

AbstractIn this study, the upscalable, substrate‐independent, and patterning characteristics of the atmospheric pressure plasma‐initiated chemical vapour deposition technique are demonstrated for the synthesis of thermoresponsive copolymer layers from N‐vinylcaprolactam (NVCL) and ethylene glycol dimethacrylate (EGDMA). An analytical multitool approach is exploited to gain insight into the chemical and mechanical surface properties of p(NVCL‐co‐EGDMA) layers and bovine serum albumin protein–surface interactions. Atomic force microscopy measurements carried out in both liquid and dehydrated conditions, reveal strong temperature‐dependent stiffness changes. The swelling and dehydration processes of the layer, monitored by quartz crystal microbalance with dissipation (QCM‐D), are reversible and durable with a lower critical solution temperature estimated at around 27°C. Finally, by combining QCM‐D and X‐ray photoelectron spectroscopy analyses, the switchable bovine serum albumin‐biofouling surface properties, triggered by temperature changes, are demonstrated.