Abstract
Among the various routes of administration, the oral route remains the most convenient and commonly employed route for drug delivery. The oral conventional drug delivery systems have some drawbacks, such as possibility of gastrointestinal destruction of labile molecules, low absorption of macromolecules, slow onset of action, and unavoidable fluctuation in the concentration of drugs which can either lead to under- or over medication with concomitant adverse effects, especially for drugs with small therapeutic index. Therefore, it became essential to design novel oral drug delivery systems to achieve quick dissolution, absorption, rapid onset of action and reduction of drug dose. Among those novel drug delivery systems are oral disintegrating tablets (ODTs). The purpose of this review article is to report the recent advances in ODT systems with emphasis on their preparations, characterizations and applications.
Highlights
The oral mucosal cavity is a very attractive and feasible site for local and systemic drug delivery, since the mucosal membranes, upon which drug delivery systems are placed, are readily accessible by the patients [1]
The oral mucosal drug delivery exhibits many advantages over other routs of drug administration, which include increased accessibility by the patients as the dosage form can be accurately placed on the desired oral cavity membrane location and can be removed in order to terminate delivery if signs of adverse reactions are observed during treatment which increases patient acceptability [1,2,3]
There are many globally marketed products that have been formulated into oral disintegrating tablets (ODTs) dosage forms
Summary
The oral mucosal cavity is a very attractive and feasible site for local and systemic drug delivery, since the mucosal membranes, upon which drug delivery systems are placed, are readily accessible by the patients [1]. ODTs prepared by freeze-drying process showed rapid disintegration and dissolution properties, but their industrial applications are limited since it is a high cost technique in equipment and packing materials [34]. This technique involves the formation of a matrix of poly-or monosaccharides using flash melting and spinning to form floss like crystalline structure, which is mixed with active/inactive ingredients and compressed into ODTs. This process can accommodate large doses of APIs with an improved mechanical strength.
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