Insights into antiretroviral treatment changes in previously naïve patients: results of a Portuguese cohort

C Silva,D Alfaiate,J Rijo,K Mansinho,D Bento,C Araújo,H Farinha,I Aldir

doi:10.1186/1758-2652-13-s4-p14

Abstract

Since the use of more tolerable and less toxic combined antiretroviral (ARV) therapy, most drug-naive HIV patients achieve viral suppression and immunologic recovery, combined with less AIDS related events. Nevertheless, drug switches are still frequent both as a mean of adherence and toxicity management and as a response to virologic or immunologic failure. The aim of the study was to analyse the number, timing and cause of modifications in the first ARV regimen in order to elucidate more about adverse drug reactions in the current HIV ARV therapy guidelines, indirect signs of adherence and premature virological failure. Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/content/pdf/1758-2652-13-S4-info.pdf Conference: Tenth International Congress on Drug Therapy in HIV Infection 7-11 November 2010 Glasgow, UK (Published: 8 November 2010) doi:10.1186/1758-2652-13-S4-P14 Cite this article as: Silva et al.: Insights into antiretroviral treatment changes in previously naive patients: results of a Portuguese cohort. Journal of the International AIDS Society 2010 13(Suppl 4):P14. Full text: PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112916/

Highlights

Purpose of the study Since the use of more tolerable and less toxic combined antiretroviral (ARV) therapy, most drug-naïve HIV patients achieve viral suppression and immunologic recovery, combined with less AIDS related events
The aim of the study was to analyse the number, timing and cause of modifications in the first ARV regimen in order to elucidate more about adverse drug reactions in the current HIV ARV therapy guidelines, indirect signs of adherence and premature virological failure
Other switch causes were the evidence of virological failure (15%), the simplification of the regimen (10%) and the adjustment during pregnancy (5%)

Summary

POSTER PRESENTATION

Insights into antiretroviral treatment changes in previously naïve patients: results of a Portuguese cohort. C Silva1*, D Bento, J Rijo, D Alfaiate, I Aldir, C Araújo, H Farinha, K Mansinho. From Tenth International Congress on Drug Therapy in HIV Infection Glasgow, UK. From Tenth International Congress on Drug Therapy in HIV Infection Glasgow, UK. 7-11 November 2010

Open Access

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