Abstract
Ischemic injuries within the motor cortex results in functional deficits that profoundly impact activities of daily living in patients. Current rehabilitation protocols achieve only limited recovery of motor abilities. The brain reorganizes spontaneously after injury, and it is believed that appropriately boosting these neuroplastic processes may restore function via recruitment of spared areas and pathways. In this presentation, I will describe our recent work on novel experimental therapies for the recovery of motor function in a mouse model of focal stroke. Specifically, we have tested experimental approaches in which physiotherapy is coupled with delivery of plasticising drugs that render the spared, undamaged pathways more sensitive to experience-dependent modifications. Moreover, we are currently exploiting optogenetic approaches to modulate specific brain oscillatory activities in phase with motor training. These combinatorial strategies hold promise for the definition of more effective rehabilitation paradigms that can be translated into clinical practice.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
