Insights From Dimensional Phenotypic Definitions of Posttraumatic Stress Disorder and Trauma in Genome-wide Association Studies

Abstract

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure InformationBiological PsychiatryVol. 91Issue 7PreviewPosttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). Full-Text PDF Open Access