Insighting the inhibitory potential of new diorganotin(IV) complexes derived from tridentate ligands: Synthesis, structural elucidation and biological evaluation

Abstract

In the present study, a series of diorganotin(IV) complexes (1-20) with the general formula R2SnL1-4 were synthesized by the reaction of R2SnCl2 (R = Me, Et, Bu, and Ph) with the hydrazone ligands (H2L1-4). Spectral and physico-analytical techniques such as multinuclear (1H, 13C, 119Sn) NMR, HRMS, FTIR, XRD and SEM studies collectively with elemental analyses were utilized to structurally elucidate the synthesized compounds. Based on the structural investigations, it can be concluded that hydrazone ligands coordinated to the central tin metal in a tridentate manner (ONO) through nitrogen atom of the azomethine group, oxygen atoms of the enolic and phenolic groups. The synthesized compounds have been screened for their in vitro antimicrobial potential against four bacterial (two Gram positive; two Gram negative) and two fungal strains. Antimicrobial activity results concluded that metal complexes exhibited better activity than free ligands towards the tested strains. Among the tested compounds, complexes 8, 12 and 20 were found to be the most active. Furthermore, the in vitro anticancer evaluation of synthesized compounds (1-20) was done against a panel of three cell lines viz; A549, MCF7 and HCT-116 using MTT assay. Complexes 5, 6 and 8 were found to be most active against the three cancer cell lines with lowest IC50 values.