Abstract
Psoriasis is an incurable dermatological disorder, characterized by increased epidermal cell proliferation. Numerous studies have focused on the modulation of polyamine (PA) metabolism in psoriatic lesions, as well as the relationship between serum homocysteine (Hcy) levels and psoriasis severity. The correlation between Hcy and PA levels has not been investigated, although both of them depend on methionine (Met) loading. The aim of this study was to examine Met, Hcy, and polyamine levels in serum, saliva, lesions, and non-affected skin to investigate the eventual relationship between their levels in skin samples and to assess the correlation of each metabolite among the tested samples. This study was conducted on 24 patients with plaque-form psoriasis vulgaris. The original LC-MS/MS method was used for quantification of analytes. Hyperhomocysteinemia was observed and the serum levels of spermidine (Spd) and spermine (Spm) were also found to be elevated. A significant increase in Met (p < 0.05) and Spm (p < 0.001) concentrations in the psoriatic plaques were found, when compared to the non-affected skin. Significant correlations were established between all polyamines levels and between methionine and spermine in both types of cutaneous samples. This study illustrates the tight relationship between Met and Polyamine levels in epidermis of psoriatic patients. Our results could be helpful in psoriasis treatment, highlighting the importance of the balanced protein diet and intake of vitamins B12 and B9.
Highlights
[4,5], and considering that homocysteine and are derived from methionine memetabolism [12,13,14,15], we aimed to evaluate the correlation between these metabolites tabolism
The disease activity was assessed according to the Psoriasis Area and Severity Index (PASI)
SAM is a conjunction unit for Hcy and polyamine metabolism, in the present article, we examined the eventual relationship between the Hcy level and the increased polyamine synthesis
Summary
Complex, and incurable skin condition, affecting the physical, mental, and the social wellbeing of patients. It is characterized by epidermal hyperproliferation and poor differentiation of keratinocytes in the basal layer of the skin, resulting in the formation of pink, heavily scaled plaques on various sites of the body. Many other metabolic abnormalities have been associated with psoriasis, including low thyroid function, colon problems, accelerated lipid peroxidation, and reduction in the total antioxidant activity [1,2]. Several studies have revealed an association between psoriasis and an increased risk of cardiovascular disease, diabetes, and atherosclerosis [10,11], highlighting the role of methionine metabolism in the pathogenesis of psoriasis.
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