Abstract
The hallmark of cancer includes an aggressive growth pattern, higher rate of locoregional recurrence and an increased propensity to disseminate and involve distant structures. It is a common feature for many cancers, especially head and neck malignant tumors, to involve neural structures. The invasion was attributed to be a part of its local aggressive nature. But, several studies have demonstrated certain tumors to show specific affinity toward neural tissues, while sparing other vital tissues in its vicinity. This affinity towards neural structures is termed as neurotrophism.(1) Studies estimating the rate of neural invasion have largely been biased. This is due to the lack of a standard definition and diagnosing criteria for evaluating neural invasion. The terminologies used to denote neural invasion include neurotrophic carcinomatous spread and perineural spread.
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