Abstract
Trichosporonosis infections have been increasing worldwide. Providing adequate treatment for these infections remains a challenge. This scoping review contains information about potential antifungals to treat this pathology. Using online databases, we found 76 articles published between 2010 and 2020 related to this topic. Classic antifungals, molecules and biomolecules, repositioned drugs and natural products have been tested against species of Trichosporon. Experimental research has lacked depth or was limited to in vitro and in vivo tests, so there are no promising new candidates for the clinical treatment of patients with trichosporonosis. Furthermore, most studies did not present appropriate scientific criteria for drug tests, compromising their quality.
Highlights
Most studies did not present appropriate scientific criteria for drug tests compromising the quality of the research
Author contributions AM Malacrida did a general search on PubMed and Web of Science databases; organized the articles according to the classification of each drug studied; wrote the abstract, introduction, methods, sections one and two of the results and discussion (Trichosporon spp. isolates and classic drugs evaluated against Trichosporon spp.), conclusion and future perspectives, acknowledgments and executive summary; created Figures 1 & 2; organized the references; and assisted in editing of the manuscript
TIE Svidzinski Wrote section five of the results & discussion (antifungal studies of natural products), created Table 1, assisted in the correction of the manuscript and helped to review
Summary
The methods of this scoping review were based on those of the study by Thayabaranathan et al [18]. Identifying the research question The research question was as follows: what types of antifungals involving classic drugs, new molecules and biomolecules, and repositioned drugs have been evaluated against Trichosporon spp.?. One author performed the initial review of publications using the following inclusion criteria: studies needed to have a focus on Trichosporon spp. antifungal susceptibility. The authors separated the articles in groups according to the treatment used (classic antifungals, molecules and biomolecules, repositioned drugs, natural products) using spreadsheets in Google Drive. Article characterization Articles included in this study were reviewed in detail by all the authors They were selected to summarize the main data. The following descriptors were used: article aim; classic drugs, molecules and biomolecules, repositioned drugs or natural products tested; study type (in vitro or in vivo); main results; characterization of clinical isolates of Trichosporon spp. The following descriptors were used: article aim; classic drugs, molecules and biomolecules, repositioned drugs or natural products tested; study type (in vitro or in vivo); main results; characterization of clinical isolates of Trichosporon spp. (number, species and material in which it was isolated); whether it had been tested on biofilm; protocol and susceptibility method used; and treatment effectiveness determined by MIC determination
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