Insight into solute-solute and solute-solvent interactions of semicarbazide hydrochloride in water and d-glucose/d-sucrose + water solutions at temperatures (293.15 to 318.15) K

Abstract

The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates (d-glucose/d-sucrose) are investigated by using volumetric, viscometric and acoustic properties. The measurements of the densities ρ, ultrasonic speeds u, and viscosities η. of semicarbazide hydrochloride in 5% and 10% d-glucose/d-sucrose + water (w/w) solutions were carried out at temperatures (293.15–318.15) K and at pressure, p = 101 kPa. The apparent molar volumes, Vϕ, limiting apparent molar volumes,Vϕ°, apparent molar compressibilities, Ks, ϕ, limiting apparent molar compressibilities, Ks,ϕ°, partial molar expansibilities, Eϕ°, transfer volumes, Vϕ,tr° and transfer compressibilities, Ks,ϕ,tr° have been calculated from the experimental data. The viscosity data were examined by using the Jones-Dole equation and the viscosity A and B coefficients were evaluated. The results are discussed in terms of solute-solute and solute-solvent interactions in these solutions. The structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of B-coefficient, dB/dT.