Inside Front Cover: DHA and EPA Prevent Seizure and Depression‐Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode‐of‐Actions in a Pentylenetetrazole‐Induced Kindling Model in Mice

Abstract

Mol. Nutr. Food Res. 2022, 66, 2200275 DOI: 10.1002/mnfr.202200275 Dietary supplementation of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) suppressed iron dyshomeostasis, oxidative stress and neuroinflammation in PTZ-induced kindling model mice. DHA and EPA are demonstrated to regulate the Nrf2 signaling and inhibit NLRP3 inflammasome activation via different mode-of-actions, implying great and different potential in the prevention and treatment of epilepsy. This is reported by Min Wen and co-workers in article number 2200275.