Abstract
DNA supersandwich structures work as gatekeepers for solid-state nanopores as part of a target-specific nanofluidic sensor for both oligonucleotides and small molecules, as shown by F. Xia, W. Guo et al. in their Communication on page 2007 ff. The DNA superstructures enhance the sensitivity and reduce the background signal, so that the biohybrid nanodevice also works well in complex mixtures, such as mammalian serum.
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