Abstract
The acylhydrazonyl hybridization of aloe emodin and azole heterocycles afforded a new unique type of framework with multitargeting antibacterial potential. The highly active compound demonstrated strong antibacterial efficacy with broad antibacterial spectrum, low hemolysis and cytotoxicity, and favorable bioavailability. The active molecule could not only cause bacterial membrane depolarization and damage the cell membrane, resulting in nucleic acid leakage, but also intercalate into DNA to impede its replication and form DNA gyrase complex to disturb the function of DNA gyrase. More details are discussed in the article by Zhou et al. on page 1741—1758.image
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