Inside Cover: Implications of Quenching‐to‐Dequenching Switch in Quantitative Cell Uptake and Biodistribution of Dye‐Labeled Nanoparticles (Angew. Chem. Int. Ed. 28/2021)

Abstract

A quenching-to-dequenching switch of fluorescence-labeled nanoparticles in biological environments is unveiled by Chun-Xia Zhao and co-workers in their Research Article on page 15426. With dye molecules in a solid state, the release and/or degradation of the dye-labeled nanoparticles in biological environments led to a several-fold increase in fluorescence intensity due to the state switch, which has significant implications in quantitative cell uptake and biodistribution studies.